In-Silico Test of Activity Andrographolide as a Natural Compound in Reducing Sugar Levels

EasyChair Preprint 7202

Abstract

The purpose of this study was to determine the bioactivity of these compounds andrographolide on metformin as a blood sugar-lowering drug. The chemical structure of the compound andrographolide found in Metformin was obtained from the literature. The target protein was 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and the control was metformin. PyMol v2.5.2 software was used to remove the water molecules. PyRx-Python Prescription 0.8 software was used to dock the target protein and the compound. When compared to control compounds, the compound andrographolide showed a greater potential for lowering drug sugar levels. The comparative affinity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase for Andrographolide is -8,0, whereas the affinity for metformin is -5,0. Andrographolide toxicity testing revealed that it was not a potential carcinogen and did not cause mutations. The water absorption of andrographolide is greater than that of the control compound.

Keyphrases: 3 hydroxy 3 methylglutaryl coenzyme A reductase, Andrographolide, Metformin

@booklet{EasyChair:7202,
  author    = {Dirgah Agum Parawansa and Andy Ariyandy and Ika Yustisia and Sulfahri Sulfahri},
  title     = {In-Silico Test of Activity Andrographolide as a Natural Compound in Reducing Sugar Levels},
  howpublished = {EasyChair Preprint 7202},
  year      = {EasyChair, 2021}}