Progress in Preclinical Research: Integration of Full-Thickness Human Skin and Autologous Immune Cells in Mouse and Rat Models

EasyChair Preprint 12255

Abstract

Utilizing animal models in biomedical research has greatly contributed to expanding our comprehension of human physiology, disease mechanisms, and therapeutic strategies. Nevertheless, the inherent distinctions between human and animal immune systems present challenges in accurately predicting human-specific responses to diseases and treatments. The emergence of humanized mouse and rat models, featuring full-thickness human skin and autologous immune cells, marks a significant advancement in addressing this disparity. This article delves into the methodology, applications, and potential impact of these sophisticated models on preclinical research and drug development.

Keyphrases: Autologous Immune Cells, Humanized Models, Preclinical research

@booklet{EasyChair:12255,
  author    = {Isabella Rossi},
  title     = {Progress in Preclinical Research: Integration of Full-Thickness Human Skin and Autologous Immune Cells in Mouse and Rat Models},
  howpublished = {EasyChair Preprint 12255},
  year      = {EasyChair, 2024}}