Advancements in Preclinical Research: Humanized Mouse and Rat Models Integrating Full-Thickness Human Skin and Autologous Immune Cells

EasyChair Preprint 12133

Abstract

The use of animal models in biomedical research has been instrumental in advancing our understanding of human physiology, disease pathology, and therapeutic interventions. However, the inherent differences between human and animal immune systems pose challenges in accurately predicting human-specific responses to diseases and treatments. The development of humanized mouse and rat models, incorporating full-thickness human skin and autologous immune cells, represents a significant stride towards bridging this gap. This paper explores the methodology, applications, and potential impact of these advanced models on preclinical research and drug development.

Keyphrases: Autologous Immune Cells, Humanized Mouse, Rat Models

@booklet{EasyChair:12133,
  author    = {Rohit Mishra},
  title     = {Advancements in Preclinical Research: Humanized Mouse and Rat Models Integrating Full-Thickness Human Skin and Autologous Immune Cells},
  howpublished = {EasyChair Preprint 12133},
  year      = {EasyChair, 2024}}