Long-Term Three-Dimensional Simulation of Cytoskeletal Rearrangement During Adipogenic Differentiation

EasyChair Preprint 13693

Abstract

Adipogenic differentiation is the process of the differentiation of a stem cell into an adipose, or fat-storing, cell. A novel, physics-based, three-dimensional multibody dynamic model of a stem cell is presented that includes the nucleus, the cytoskeleton, the lipid droplets, the cellular envelope, and focal adhesion points. The cellular model proposes the hydrostatic pressure difference between the inside and outside of the cell as the mechanism of maintaining its structural integrity. Obtaining long-term dynamic simulation of cellular processes has been infeasible even with the employment of supercomputers. The scaling approach presented herien, based on the method of multiple scales (MMS), effectively separates the computational time from size and distribution of the cellular models' elements. Employing the scaling approach enables the production of the 14-day time history of this process on a desktop computer in less than 1 hour and 9 minutes.

Keyphrases: Adipogenesis, Adipogenic Differentiation, Biomechanics, Cellular Simulation, Long-term simulation, Method of multiple scales, Nanodynamics

@booklet{EasyChair:13693,
  author    = {Manoochehr Rabiei and Alan Bowling},
  title     = {Long-Term Three-Dimensional Simulation of Cytoskeletal Rearrangement During Adipogenic Differentiation},
  howpublished = {EasyChair Preprint 13693},
  year      = {EasyChair, 2024}}