Association of Plasma Adiponectin Levels and ADIPOQ Rs266729 Gene Variants with the Risk of Obesity in a Vietnamese Population

EasyChair Preprint 14239

Abstract

Obesity is a growing metabolic health issue in Vietnam. Lower adiponectin levels are reported in obesity. Variants of the adiponectin gene are promising candidates in the study of obesity-related conditions due to their possible impact on insulin production. Therefore, we investigated the associations of rs266729 gene variants with obesity risk and adiponectin levels. Methodology We collected anthropometric and biochemical data from 100 obese adults and 100 age- and sex-matched control subjects. Obesity was defined as having both a high body mass index (≥ 25 kg/m2) and central obesity. Adiponectin levels were measured using a latex-enhanced immunoturbidimetric method. The genotyping of rs266729 was analyzed using tetra-primer ARMS-PCR methods. Results In this study, the prevalence of rs266729 genotypes CC, GC, and GG was 68%, 28%, and 5%, respectively. Compared to genotype CC, subjects with genotypes GG and GC presented significantly higher obesity risk with odds of 1.89. The median adiponectin level in the obese subjects was 4.35 µg/ml, significantly lower compared to 9.31 µg/ml in the controls. Adiponectin levels were independently associated with obesity in multivariate analysis (OR=0.75, p<0.001). Nevertheless, adiponectin levels did not differ between rs266729 genotypes. Conclusion and Discussion The association of plasma adiponectin and ADIPOQ rs266729 gene variants was determined. However, the link between adiponectin and rs266729 gene variants was not confirmed. Further investigations, including extensive and diverse populations in Vietnam, are needed to clarify these findings.

Keyphrases: ADIPOQ, Adiponectin, Obesity

@booklet{EasyChair:14239,
  author    = {Phat Tung Ma and Nam Quang Tran and Linh Le Hoang Gia and Nien Vinh Lam},
  title     = {Association of Plasma Adiponectin Levels and ADIPOQ Rs266729 Gene Variants with the Risk of Obesity in a Vietnamese Population},
  howpublished = {EasyChair Preprint 14239},
  year      = {EasyChair, 2024}}